Chloromethyltrimethylsilane
[CAS 2344-80-1]

Identification

• Classification: Chemical reagent >> Organic reagent >> Silane
• Name: Chloromethyltrimethylsilane
• Molecular Formula: C₄H₁₁ClSi
• Molecular Weight: 122.67
• CAS Registry Number: 2344-80-1
• EC Number: 219-058-5
• SMILES: C[Si](C)(C)CCl

Properties

• Density: 0.9±0.1 g/cm³ Calc.^*, 0.884 g/mL (Expl.)
• Melting point: 98 - 99 °C (Expl.), 98 - 99 °C (Expl.)
• Boiling point: 96.0±13.0 °C 760 mmHg (Calc.)^*
• Flash point: -2.8 °C (Calc.)^*, -2 °C (Expl.)
• Solubility: water insoluble (Expl.)
• Index of refraction: 1.397 (Calc.)^*, 1.418 (Expl.)

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS02;GHS07;GHS09 DangerGHS02
• Risk Statements: H225-H315-H319-H335-H411
• Safety Statements: P210-P233-P240-P241-P242-P243-P261-P264-P264+P265-P271-P273-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P370+P378-P391-P403+P233-P403+P235-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Flammable liquids	Flam. Liq.	2	H225
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Acute hazardous to the aquatic environment	Aquatic Acute	2	H401
Skin corrosion	Skin Corr.	1B	H314
Acute toxicity	Acute Tox.	4	H302
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H332

• Transport Information: UN 1993

chemBlink Chemical Story

Chloromethyltrimethylsilane matters because the trimethylsilyl group and reactive chloromethyl group make this small organosilicon compound a useful synthetic building block, with neighboring silicon also able to influence carbocation chemistry. This connection between molecular structure and observable behavior is more informative than a simple list of uses. CAS 2344-80-1 identifies the substance in this chemBlink record, while its practical significance comes from the way its functional groups, composition, or material structure control reactivity and physical properties.

The broader lesson is that chemical identity alone does not determine performance. Conditions such as pH, temperature, formulation, concentration, molecular distribution, or biological environment can decide whether the same underlying chemistry is useful, inactive, or hazardous. For chemists, Chloromethyltrimethylsilane is therefore a useful case study in connecting molecular-scale behavior with a real laboratory, industrial, biological, or materials-science outcome.

References: NIST Chemistry WebBook, CAS 2344-80-1; Brook, Silicon in Organic Chemistry

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